NPHS2Variation in Sporadic Focal Segmental Glomerulosclerosis
نویسندگان
چکیده
منابع مشابه
Genetic testing for podocyte genes in sporadic focal segmental glomerulosclerosis.
Focal segmental glomerulosclerosis (FSGS) is a clinicopathological entity that manifests with severe proteinuria and/or nephrotic syndrome. FSGS is considered to represent a pattern of glomerular scarring, rather than a specific disease entity. The histological hallmark of FSGS is characterized by sclerosis that involves some, but not all, glomeruli and the affected glomeruli typically show inv...
متن کاملA role for genetic susceptibility in sporadic focal segmental glomerulosclerosis.
Focal segmental glomerulosclerosis (FSGS) is a syndrome that involves kidney podocyte dysfunction and causes chronic kidney disease. Multiple factors including chemical toxicity, inflammation, and infection underlie FSGS; however, highly penetrant disease genes have been identified in a small fraction of patients with a family history of FSGS. Variants of apolipoprotein L1 (APOL1) have been lin...
متن کاملFocal Segmental Glomerulosclerosis.
Focal segmental glomerulosclerosis (FSGS) is a leading cause of kidney disease worldwide. The presumed etiology of primary FSGS is a plasma factor with responsiveness to immunosuppressive therapy and a risk of recurrence after kidney transplant-important disease characteristics. In contrast, adaptive FSGS is associated with excessive nephron workload due to increased body size, reduced nephron ...
متن کاملIdiopathic focal segmental glomerulosclerosis.
Idiopathic focal segmental glomerulosclerosis (FSGS) is a primary glomerular disease that essentially represents a form of chronic, progressive renal fibrosis for which there is no discernible cause. Often presenting with or eventually manifesting the nephrotic syndrome, this disease is increasing in incidence in both children and adults. Therapy continues to be a challenge, although some patie...
متن کاملCollapsing Focal Segmental Glomerulosclerosis
Background and objectives: Treatment with IFN is rarely associated with nephrotic syndrome and renal biopsy findings of minimal-change disease or FSGS. Design, setting, participants, & measurements: We report 11 cases of collapsing FSGS that developed during treatment with IFN and improved after discontinuation of therapy. Results: The cohort consists of seven women and four men with a mean age...
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ژورنال
عنوان ژورنال: Journal of the American Society of Nephrology
سال: 2007
ISSN: 1046-6673,1533-3450
DOI: 10.1681/asn.2007030319